Cyclosporin A suppresses insulin autoantibodies and heterologous insulin antibodies in type I diabetic children.
L Castaño, C Boîtard, PF Bougnères - Diabetes, 1988 - europepmc.org
L Castaño, C Boîtard, PF Bougnères
Diabetes, 1988•europepmc.orgWe report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present
before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic
children. CsA also reversibly blocks the production of antibodies after exogenous insulin
injection, whereas high titers of heterologous insulin antibody are observed in all type I
patients not receiving CsA.
before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic
children. CsA also reversibly blocks the production of antibodies after exogenous insulin
injection, whereas high titers of heterologous insulin antibody are observed in all type I
patients not receiving CsA.
We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.
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